“Are we talking about the inbreeding problem? It sounds like it,” Dinah said.
“Loss of heterozygosity. Yes. I happen to know something about it. It’s why I was chosen as a member of the General Population.”
“Because of your work on black-footed ferrets and so on,” Ivy said.
“Yes. This is a closely analogous problem. But the point I would like you all to keep in mind is that we solved that problem in the case of the black-footed ferrets and we are going to solve it again.”
She said it with force and confidence that silenced the others for a few moments and left them looking at her for more.
Moira went on. “I think we all have at least an intuitive understanding of this, yes?”
That one was aimed at Julia, who looked mildly peeved, and bit off the following: “My daughter had Down syndrome. That is all I will say.”
Moira acknowledged it with a nod, then went on: “Everyone has some genetic defects. When you are breeding more or less randomly within a large population, there’s a tendency for those errors to be swamped by the law of averages. Everything sort of works out. But when two people sharing the same defect mate, their offspring is likely to have that defect as well, and over time we see the usual unpleasantness that we all associate in our minds with inbreeding.”
“So,” Luisa said, “if we follow the plan you have laid out, and begin, a few years down the road, with seven groups of what amount to siblings or cousins—”
“It’s not enough heterozygosity, to answer your question,” Moira said. “If you have a genetic predisposition to any disease, for example—”
“Alpha-thalassemia runs in my family,” Ivy said.
“That’s a fine example,” Moira returned. “As it happens, Old Earth compiled vast databases on such things before its destruction. All of which are in there now.” She gestured in the direction of her lab. “We have a very good idea which defects, on which chromosomes, are responsible for alpha-thalassemia. If you supply me with an ovum, I can find those defects and I can fix them before we begin parthenogenesis. Your offspring will be free of that defect. Barring some random future mutation, it’ll never return.”
Dinah raised her hand. “My brother was a carrier of cystic fibrosis. I haven’t been tested.”
Julia raised hers. “Three of my aunts died of the same form of breast cancer. I’ve been tested. I know I carry that defect as well.”
“The same answer applies in all of these cases,” Moira said. “If there’s a genetic test for it, then it means, by definition, that we know which defects are responsible for it. And knowing that, we can perform a repair.”
A new voice joined the conversation. “How about bipolar disorder?”
Everyone looked at A?da.
She would live out the rest of her life, and go to meet her maker, without having a friend, or even a friendly conversation. So, no one was in a receptive frame of mind about her question. But the mere fact that she’d asked it suggested a level of introspection they hadn’t seen from her before. Moira considered it.
“I would have to do some research. I think that it does run in families to some extent. To the extent that it can be traced to particular locations on particular chromosomes, it can be treated like any other disease,” Moira said.
“Do you believe it should be?” A?da asked.
Everyone looked automatically at Luisa, who nodded. “We are long past the point of thinking of mental illnesses as somehow a lesser kind of disease than physical. Such disorders should, in my opinion, be addressed in just the same way.”
“Do you believe it must be?”
Luisa colored slightly. “What is the point of these questions, A?da?”
“I have done research on it,” A?da said. “Some say that bipolarity is a useful adaptation. When things are bad, you become depressed, retreat, conserve energy. When things are good, you spring into action with great energy.”
“And your point is . . .”
“Will you treat this condition in my offspring against my will? What if I want to have a lot of little bipolar kids?”
In the flustered silence that followed, Camila spoke. “What about aggression?”
Everyone turned to look at her, as if unsure they had heard her correctly.
“I’m serious,” she said. She looked toward A?da. “I don’t mean to trivialize the suffering that your condition causes. But over the course of history, aggression has caused a far larger amount of pain and death than bipolar disorder or whatever. As long as we are fixing those aspects of the human psyche that lead to suffering, should we not eliminate the tendency to aggressive behavior?”